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Both the semaglutide and tirzepatide shortages that made compounding legally available were declared resolved in 2024 and 2025, the compounding wind-down deadlines have passed, and in April 2026 the FDA proposed closing the remaining legal pathway entirely

Try using your TDEE estimate for 23 weeks to track your average intake and weight trend, and then fine-tune based on the results

However, even substantial life changes may not be enough to produce weight loss results on their own

The exact cause remains unclear, but fibromyalgia is thought to involve abnormal pain processing in the central nervous system, leading to heightened sensitivity to pain signals (central sensitisation)

Starting BMI People with higher starting BMIs tend to lose more weight in absolute terms, though percentage weight loss is broadly similar across BMI categories in the clinical trials 1,2