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Some consider it a serious concern, while others see it as clinically insignificant (Zhang and Zhao, 2016

10.1155/2020/2948282 63 LiuX.ShaoL.LiuX.JiF.MeiY.ChengY.et al (2019)

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This is due to wide variations in absorption rates

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12 We did not observe a statistically significant difference in the incidence of NAION between groups, likely due to the limited number of events and resulting imprecision in effect estimates