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As observed in other organ models, most reported kidney-on-chip studies still rely on immortalized cell lines (176180), although recent work has increasingly explored patient-derived primary cells, spheroids, and organoids to establish autologous renal chips (166, 181185)

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Macrophage polarization by SeC@PA MN in vivo An important indicator of the inflammatory response is the phenotype of macrophages 44

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This process is mediated by the activation of AMPK and improved mitochondrial function, optimizing cellular energy metabolism (176)