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Around a third of GLP-1 users who reduced their substance use (29%) took it a step further and quit entirely

Researchers selecting compounds must now navigate a complex hierarchy of affinity, ranging from the highly specific Semaglutide to the dual-agonist Tirzepatide, and now the experimental frontier of triple-agonists like Retatrutide

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The theory behind combining them is sound

J Clin Endocrinol Metab 2022

There are also more serious risks to be aware of