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[5] [6] In women, obesity is linked to: Anovulation and irregular menstrual cycles : Excess adipose tissue produces oestrogen and inflammatory mediators that disrupt the hypothalamic-pituitary-ovarian axis, leading to irregular or absent ovulation

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Similarly, in primary cardiac fibroblasts, GLP-1R agonism inhibited TGF- signalling activity and expression of ECM proteins, including COL1A1 and COL3A1 [25]