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J Androl (2009) 30(5):53440

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Furthermore, sodium-containing formulations should be judiciously avoided in topical preparations, while fully optimized delivery systems are indispensable for enhancing transdermal NSAID penetration, enabling precise targeting to inflammatory foci, and achieving synergistic therapeutic outcomes through dual anti-inflammatory and crystal-dissolving mechanisms ( 4.3.3 Hydrogel and fibrous polymeric carrier systems Hydrogel and fibrous polymeric carrier systems enable precise targeting and multi-mechanistic synergies in gout therapeutics through localized delivery, sustained release, and environmental responsiveness, thereby enhancing efficacy while reducing adverse effects