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70,71 Additionally, ASOs can form a double-stranded structure complementary to miRNA, leading to its degradation and causing gene upregulation

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A recent study showed that Lactobacillus acidophilus supplementation in mouse models of NAFLDHCC increased portal-vein and hepatic levels of valeric acid (C5:0), and this metabolite reduced hepatic inflammation via inhibition of pathways downstream of Rho-GTPase, implying a role for non-protein microbial metabolites in modulating liver disease progression (83)

Ex-4 also reverses endothelial cell aging in the mouse brain, which is characterized by zonation-dependent transcriptomic changes