Mechanistically, cGAS is a cytosolic sensor that binds dsDNA independent of sequence [96]
Generally, these xenobiotic compounds are lipophilic, whereby they are likely to bind to lipid membranes and accumulate in adipose tissue as well as to be transported by lipoproteins in the blood and reach different compartments/organs
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In patients with human immunodeficiency virus (HIV), dermatologic reactions to sulfonamide antimicrobial agents occur 10 to 20 times more frequently compared to immunocompetent patients