Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis
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Se explicara por cambios asociados a la inhibicin de la reabsorcin tubular de Na+que resultan en disminucin de la presin intraglomerular y por tanto de la hiperfiltracin que es uno de los principales mecanismos responsables de la nefropata DM102,104,121
Researchers started describing it as a genome reset, because the pattern in aged cells shifted back toward what youd expect from younger tissue (PMID: 25815981)
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