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Furthermore, therapeutic mechanisms such as alternative splicing ASOs that have FDA approval for non-NDD pathologies such as Spinraza (SMA) and Eteplirsen (DMD) may provide a strong basis for further studies using these ASOs for genes with splice mutations implicated in NDDs

10.1007/s00403-010-1045-4

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However, appropriately buffered formulations or sequential application protocols (retinoid evening application, GHK-Cu morning application) can enable combined use while maintaining stability and tolerability