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While still contradictory, some studies have highlighted a positive association between daily smoking, and the increase in prevalence, frequency, and severity of hand eczema .However, this negative influence of smoking on eczema can be reinforced in manual workers who are simultaneously exposed to irritants, mechanical trauma, and work in a humid environment

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demonstrated that nicotine stimulated intracellular hydrogen peroxide (H2O2) accumulation, thus leading to the inhibition of glyoxalase 1 (Glo1), which is an enzyme involved in the detoxification of methylglyoxal (MG)

doi: 10.1038/s41390-018-0239-x 62 DohertyDFNathSPoonJForonjyRFOhlmeyerMDaboAJet al

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