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Think about a 16-year-old patient who weighs 400 pounds

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Up to 40% of total weight lost on GLP-1 drugs is lean mass (muscle), not fat

This is why losing muscle in the long run is a big problem

Notably, GLP-1 exerts significant effects on glycemic control by promoting glucose-stimulated insulin secretion and suppressing glucagon release.13 Additionally, it reduces appetite and food intake.1,4,5 Glucagon-like peptide-1 receptor agonists (GLP-1RAs), which mimic the action of endogenous GLP-1, have become integral to the treatment of type 2 diabetes mellitus (T2DM)