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This vascular change is largely driven by a higher production of NO in endothelial cells [25]

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This has led Russell12 to redefine FMS as Central Allodynia and Donaldson et al to call FMS a type of CNS Myalgia.27 This presence of CNS dysfunction, fibro-fog, memory problems, lowered pain threshold, sleep disorders, and other brain-processing difficulties is what appears to be the major differentiating factor between the categories of Classic FMS and Pseudo FMS

Previously, plasmapheresis was prohibited under M1

2013, and FDA's December 2024 review lists the same trial set