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In phase 1 studies, brensocatib reduced NE levels in blood with acceptable safety and pharmacokinetics (194, 201), prompting a 24-week phase 2 WILLOW trial conducted in 256 patients with bronchiectasis, in which treatment with 10 mg or 25 mg of brensocatib daily for 24 weeks significantly prolonged time to exacerbations compared with placebo (115, 202)