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In a typical healthy weight loss scenario, about 75 percent of weight loss comes from fat, while roughly 25 percent comes from fat-free mass, including muscle, says Sriram Machineni, MD, an endocrinology, diabetes, and metabolism expert at Montefiore Health Systems in New York City

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Dopamine plays a crucial role in the transition from nonrapid eye movement (NREM) sleep to rapid eye movement (REM) sleep through a transient increase in the basolateral amygdala (BLA), acting on D2 dopamine receptors to initiate the NREM-to-REM shift