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The review focuses explicitly on Glucagon-Like Peptide-1 (GLP-1) receptor agonists, newer multi-receptor agonists, and emerging oral small-molecule therapies

GIP receptor agonism independently contributes to slower gastric transit as well, though the net magnitude is similar to semaglutide at therapeutic doses [2]

Hence, we strongly encourage the adoption of GLP-1RA plus SGLT2i combination therapy in T2DM patients with uncontrolled metabolic risks, i.e., especially those who need to lose weight and/or control high blood pressure

Insurance coverage may vary

The importance for prescribers to document and justify all prescribing decisions for unlicensed/off label use is paramount for good clinical governance standards

Conclusion Injectable GLP1 medications need more than generic calorie counters or step trackers can provide