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when most cells were in the G0/G1 phase of the cell cycle, suggesting that cells need a reduced nuclear environment to proliferate

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The presence of two variants ( ALDH3A1*2 and ALDH1A1*2 ) is known to reduce the activity of the ALDH enzyme, which affects the detoxification capacity of cyclophosphamide (CYC), theoretically increasing the risk of toxicity from CYC (Ekhart et al., 2008)