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doi: 10.1038/s41586-023-06983-9 67 ZhangDD

NRP1 binds to S1 through a multi-basic furin-cleavage site (FCS) and promotes S1 shedding to expose the S2 site for TMPRSS2 priming 64

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Amlodipine reacts with different cellular regulators, e.g., mitogen-activated protein kinases (MAPKs), transcription factors, and cell cycle proteins, which may affect the maintenance of pancreatic -cell function and insulin sensitivity and control the cellular reply to oxidative stress and abnormal protein synthesis induced by AGEs 95

[122] Studies in the 1980s and 1990s revealed the activities of NAD + and NADP + metabolites in cell signaling such as the action of cyclic ADP-ribose, which was discovered in 1987