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Initially, NOS catalyzes the 5-electron oxidation of the guanidine nitrogen of L-Arg to form N -hydroxy-L-Arg (NOHLA), which transfers one molecule of nicotinamide adenine dinucleotide phosphate (NADPH) to flavin adenine dinucleotide and flavin mononucleotide through oxygen activation on heme

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In the mitochondria, NADPH is derived largely from NADH through the activity of the NNT

Th17 cell ferroptosis can result in DAMP release and cell death, which exacerbates inflammation (73, 74)

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