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The US FDA, EMA, UK MHRA, and Health Canada have not authorized them for human therapeutic use

Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II)

Washing packed red blood cells decreases red blood cell storage lesion formation

In the United States, the FDA Biomarker Qualification Program was designed to formalize the use of biomarkers in therapeutic development, but progress has been slow

The practical protocol approach for most researchers starts at a lower dose, typically 2mg weekly, and escalates every three to four weeks based on tolerance