however, these findings cannot reliably distinguish primary, cell-autonomous mitophagy defects in epithelial cells from secondary changes driven by aging, endoplasmic reticulum stress, inflammation, or established fibrosis
doi: 10.1016/j.lfs.2023.121709 187 TengG.LiuZ.LiuY.WuT.DaiY.WangH.et al
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He adds that the method of ingestion also doesnt matter that much: [When] you reach a similar concentration in the blood, its gonna make you feel sick, whether you eat it, smoke it or vape it though he notes that smoking hits the bloodstream quicker than edibles, which can cause you to feel sicker more quickly
If you do overdo it, forgive yourself
Tobacco cigarettes burn at around 800 degrees Celsius, but the IQOS only heats the tobacco to 350 degrees, delivering a mouthful of tobacco-flavored vapor, but no smoke and tar