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Fasting insulin or insulin-resistance risk when appropriate

Classically, in enteroendocrine L cells, proglucagon is cleaved by PC1/3 to produce GLP-1, whereas in the alpha-cell, proglucagon is processed by PC2 to yield glucagon ( Indeed, several early studies using GLP-1 immunoreactivity (46, 47) and HPLC (48) of pancreatic and intestinal tissue sections detected GLP-1 in the pancreatic tissue, albeit at a considerably lower concentration than that of glucagon

hence, DPP-4 signaling in immune cells seems independent of its catalytic enzyme activity (86)