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Rashmi Sarkar, pooled five randomised controlled trials plus one open-label study on oral glutathione

Kubota S, Haraguchi T, Kuwata H, Seino Y, Murotani K, Tajima T, Terashima G, Kaneko M, Takahashi Y, Takao K, Kato T, Shide K, Imai S, Suzuki A, Terauchi Y, Yamada Y, Seino Y, Yabe D

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Under the trial-product estimand (assuming participants stayed on treatment), the reduction was 22.7%

Finally, the population cohort in this research was restricted to individuals of European ethnicity, limiting the universality of our results

These results indicate that fibroblast-derived matrix is able to regulate adipogenic and osteogenic differentiation capacity of MSC, being the modification promoted by LOX/BMP1 capable to fine-tune this ability