Since previous studies have linked the activation of NRF2 with the repression of lipogenic gene expression 64 , we reasoned that GSH depletion causes oxidation and consequent inactivation of KEAP1 (a repressor of NRF2), thus leading to increased antioxidant and decreased lipogenic gene expression
Ferrer CM, Lynch TP, Sodi VL, Falcone JN, Schwab LP, Peacock DL, et al
The pathogenesis involves a combination of cell-mediated and humoral immune responses, initiated in genetically predisposed individuals upon exposure to environmental triggers
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BMC Cancer 18 , 784 (2018)
after 7 days of exposure, it also caused a significant reduction in cardiac shortening fraction only in the GPx1-deficient mice, an indication that GPx1 deficiency sensitized mice to angiotensin II-mediated left ventricular dysfunction [42]