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First, TNFR-1 contains an intracellular death domain and is involved in detrimental effects such as neuronal apoptosis and neurodegeneration, whereas TNFR-2 is usually involved in neuroprotection.6364 Thus, TNFR-1 and TNFR-2 are differentially involved in proliferation and differentiation of hippocampal neural stem cells

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2 The spectrum of MASLD encompasses metabolic dysfunction-associated steatotic liver, metabolic dysfunction-associated steatohepatitis (MASH), liver fibrosis, and cirrhosis, representing a significant global public health threat