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The molecules were submitted to an energy minimization step, which was performed by 75 iterations using the OPLS4 force field, and used as inputs for molecular docking to the target enzyme

10.1002/art.10496 64 LoeserR

Keratinocytes interact with immune cells recruited to the site of inflammation and increase the expression of adhesion molecules, which enables immune cells to adhere to the vascular endothelium ( According to the literature, oxidative and nitrosative stress plays a role in the progression of chronic spontaneous urticaria (CSU) ( Table 1 ) (164, 165)

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GHK-Cu acts as a powerful anti-inflammatory agent, soothing skin and helping to prevent the cascade of damage that can follow