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These studies confirm that isoliquiritigenin exerts its anti-RA effects by activating the Nrf2/HO-1-mediated pathway to mitigate oxidative stress, inhibit chondrocyte apoptosis and extracellular matrix degradation, and alleviate joint and muscle damage ( Quercetin (Figure 6I), a major active flavonoid metabolite isolated from Taxillus chinensis (DC.) Danser and other medicinal plants, exhibits a variety of biological activities, including anti-inflammatory, antioxidant, and immune-regulatory properties

falciparum TrxRs, and inhibitors selective for individual enzymes could be developed

SARA is characterized by a drop in pH due to VFA and lactate accumulation

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Rozen, R., Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition