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It is more frequently diagnosed in women than in men, with a ratio of approximately 2:1

A case-control study of 164 patients with dementia of Alzheimer's type included 76 cases in which the diagnosis of Alzheimer's disease was confirmed by examination of brain cells after death

The goal is not isolated optimization

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In hemoglobinoathies (mainly SCD and thalassemias, but not limited to), the hemoglobin S and globin dimers are prone to lose heme through the formation of unstable hemichromes [237]

A deeper understanding of these interconnected pathophysiologic mechanisms will facilitate the development of targeted therapies beyond cysteamine, optimizing treatment approaches to mitigate disease progression [146]