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Dual GLP-1/GCGR agonism, but not isolated GLP-1R agonism (dulaglutide), additionally increases hepatic expression of amino acid transporters and carbamoyl phosphate synthase 1 (CPS-1) (9), a key enzyme in ureagenesis

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Additionally, repeated use and withdrawal can result in persistent overactivation of the HPA axis, causing elevated cortisol levels and disrupted negative feedback mechanisms 68,69,70,71

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HPC film is ideally suited for administration of glutathione by the orobuccal route