Mark Gilbert, a nutritionist at PortionIQ, a science-led range of GLP-1 friendly shakes, bites, soups and drinks, says people are at risk of dehydration when calories are substantially restricted
Ursodeoxycholic acid ( UDCA ) is the first-line treatment for PBC , shown to improve liver biochemistry and delay disease progression
One of the striking features that was consistently observed in multiple cohorts across diverse geographical locations is the reduction of butyrate-producing bacteria in individuals with T2D
Common gastrointestinal effects include: Bloating and gas : Increased fermentation activity from probiotic bacteria can produce excess intestinal gas, causing abdominal distension and discomfort Mild diarrhea or loose stools : Changes in gut flora composition may temporarily alter bowel habits Abdominal cramping : Some individuals experience mild to moderate cramping as their digestive system adapts Nausea : Less common but reported, particularly when supplements are taken on an empty stomach These symptoms are generally mild, self-limiting, and often resolve within days to weeks as the microbiome equilibrates
Dose Adjustments Following Weight Loss Thyroid medication dosing is often weight-dependent
Sleep and stress management Poor sleep and chronic stress both promote weight regain through hormonal mechanisms