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From the payer perspective, the adjusted total cost per patient for the GLP-1RA group was higher than that for the insulin group by US$969, and from the healthcare sector perspective, the adjusted total cost per patient for the GLP-1RA group was lower than that for the insulin group by US$342

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Research indicates that individuals with severe depression exhibit lower ATP and glucose metabolism in brain regions associated with mood regulation, including the bilateral insula, nucleus accumbens, and cingulate gyrus (Su et al., 2014)