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Decreasing the expression of key proteins in SCAP pathways induced senescent cell death, promoting the discovery of small molecules and compounds that target these SCAPs, referred to as senolytics

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FOXO4-DRI shows potential as a treatment targeting the senescence and apoptosis resistance, and holds promise as an approach to prevent the aggressiveness and relapse of keloids

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Barreto G, Santos-Galindo M, Diz-Chaves Y, Perna O, Carrero P, Azcoitia I, Garcia-Segura LM