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This may be one of the main reasons that many promising therapeutic strategies targeting HSP70 have failed

J Mol Med 95 , 323333 (2017)

The majority of dislocations are anterior (forward), but posterior and inferior dislocations can also occur

Most research is on rats and mice

The condition involves dysregulation of neurotransmitters, inflammatory mediators, and stress response systems, producing a constellation of symptoms extending far beyond pain to include crushing fatigue, unrefreshing sleep, cognitive dysfunction known as fibro fog, and heightened sensitivity to temperature, sound, and light

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