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Interestingly, this NMDA receptor-mediated activity-dependent myelination requires the simultaneous presence of glutamate and growth factors like brain derived neurotrophic factor (BDNF), hinting at the importance of surrounding glial cells (Lundgaard et al., 2013)

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In a rat model of hyperthyroidism induced by levothyroxine sodium, total extract and large polar iridoid fractions of Scrophulariae Radix significantly decrease key enzymes involved in glycolysis and the tricarboxylic acid cycle under hypermetabolic conditions (103)

However, factors like poor diet, stress, pollution, and aging can deplete glutathione levels

Oxidative Stress Theory According to the oxidative stress theory, intra-epidermal buildup of reactive oxygen species the most well-known of which is hydrogen peroxide (H2O2), whose concentration can reach up to one millimole is the primary cause of vitiligo

It is not something most people want to talk about in public