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5 Mechanisms of lung damage in adolescent E-cigarette users Multiple mechanistic pathways underline the pulmonary damage observed in youth who vape, involving oxidative injury, inflammatory signaling, cellular toxicity, immune dysfunction, and interference with normal lung development (51)

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In the population group, the CDS-5 score was higher than the FTCD overall, among women, in the younger age group and among those lasting more to smoke their first cigarette after waking up, that is, in smokers who are more likely to be more affected by psychosocial dimensions of dependence

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