This was the opposite of what we imagined we would find. Despite people with the PAM variant having higher circulating levels of GLP-1, we saw no evidence of higher biological activity
Interleukin6 enhances insulin secretion by increasing glucagonlike peptide1 secretion from L cells and alpha cells
Additionally, the altered gastrointestinal motility may affect the timing of food delivery to the small intestine where natural enzymes from the pancreas act
Simultaneously, GLP-1 suppresses glucagon secretion (also in a glucose-dependent manner), preventing excessive glucose production by the liver
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