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10.1016/j.celrep.2021.109374 91 ZhengZ.ZongY.MaY.TianY.PangY.ZhangC.et al (2024)

KYN binding to AhR leads to differentiation of immature CD4+ T cells into inhibitory T cells

The experimental autoimmune encephalomyelitis (EAE) animal model of MS has proven the pathogenic function of myelin-reactive T cells in MS pathogenesis (Laaker et al., 2021)

From basic mechanisms to clinical research

Use in Specific Populations Safety and effectiveness in children have not been established

Which compound has more published research data available?# Tirzepatide has substantially more published research data as of 2026 because it entered clinical development earlier and has a larger completed trial program across the SURPASS and SURMOUNT study families covering type 2 diabetes, obesity, sleep-disordered breathing, and cardiometabolic endpoints