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In contrast, cigarette advertising and promotional spending have increased from $1.2 billion in 1980 to $8.1 billion in 2021, with the majority of the latter coming in the form of wholesale and retail price discounts

Study Characteristics The 22 studies analyzed include seven cohort studies 19, 23, 39, 40, 43,44,45 and fifteen case-control studies 17, 18, 20,21,22, 24,25,26,27,28, 32, 37, 38, 41, 42 , with a total of 795,632 cases and 1,829,256 control participants

Philip H Smith, Miami University

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