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This product is a medicine

The abnormal proliferation of FLS results from a loss of contact inhibition that plays a critical role in RA by producing inflammatory cytokines and proteinases, such as matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) that perpetuate joint destruction

10.1093/ckj/sfac090 19

Taking metformin has been known to increase constipation, bloating, belly cramps and diarrhoea in some patients

Supplements discussed include branched-chain amino acids, creatine, fish oil, hydroxymethylbutyrate, protein powders and shakes, urolithin A, ursolic acid, and vitamin D

If nausea persists beyond 2 to 3 weeks at a given dose or becomes severe enough to prevent adequate nutrition, contact your healthcare provider