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Dosages of around 300800 mg per day for 816 weeks have been found to be safe and well tolerated in humans

Additionally, studies show that taking loading doses of creatine can lead to GI discomfort, including bloating, in some people

F., Mumford, S

It may thus be suggested that direct exposure of the gut to the microbiome - capable of synthesizing thiamine antagonists or possessing thiamine-degrading thiaminase II - may first of all affect the gut, leading to gastrointestinal beriberi, especially under conditions of SIBO or other disturbances of the gut microbiome

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Eric Niederkofler, Ph.D