TB-500 requires much higher doses (22.5mg vs
Ramirez et al., 2022
CVD = cardiovascular disease
10.1038/s41598-017-15222-x 59 WuR.WangH
Superoxide anion (O 2 - ), hydroxyl (OH ), alkoxy radicals (RO ), peroxyl radicals (ROO ), nitric oxide radical (NO ), nitrogen dioxide (NO 2 ), and carbonate radical (CO 3 - ) are the few examples of radical ROS whereas non-radical ROS include singlet oxygen ( 1 O 2 ), hydrogen peroxide (H 2 O 2 ), hypochlorous acid (HOCl), and peroxynitrite (ONOO - ) species which can readily trigger free radical reactions in organisms [23, 24]
Three lead candidates (Elephasin-1.5, Mylodonin-2, and Staph-2) were validated, exhibiting minimum inhibitory concentrations (MICs) of 28 M against Clostridium perfringens, 1-4 M against Enterococcus cecorum, and 16 M against avian pathogenic Escherichia coli (APEC), with no hemolysis up to 64 M