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Studies have demonstrated that ferroptosis induction in MM cells triggers DNA methylation and histone modification changes associated with cellular senescence

Only one study investigated its role in the cardiovascular system

Proc Natl Acad Sci USA 1999;96:72205

In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

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Am J Physiol 1994