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Curcumin increases Nrf2 expression and its downstream targets HO-1 and GPX4 in hepatocytes, 452 cardiomyocytes, 504 neurons, 679 renal tubule cells 865 and chondrocytes, 882 protecting against diseases by inhibiting ferroptosis

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Indeed, although having the typical GST fold, none of the cysteine of the CPxC signature found in plant sequences is conserved in other organisms notably mammals, and there is no evidence for a cysteine involvement or for a requirement of GSH for their function

An overview in health and disease

Glutathione is studied here as a reference compound for redox biochemistry, antioxidant pathway research, and comparative chemistry of natural sulfur-containing peptides