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GLP-1 induced activation of PKA increases Pdx1 expression and translocation of Pdx1 to the nucleus, where Pdx1 binds to the insulin promoter to initiate insulin expression and synthesis (Figure 5) [490,524]

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40 , i3i17 (2025)

Weight re-gain since discontinuation was significantly associated with reinitiation

Managing Unexpected Bleeding While Taking Wegovy If spotting occurs whilst taking Wegovy and a medical evaluation has excluded concerning gynaecological pathology, there are several approaches to managing this symptom