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Nature 385 , 165168 (1997)

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Its effects are mediated by activation of GLP-1 receptors (GLP-1Rs) in the central nervous system, which help regulate hunger signals that prompt people to eat when hungry and stop when satisfied (Fig

In other embodiments, the delivery system comprises multiple syringes, each syringe of the multiple syringes contains at least one component of the formulation such that each component is pre-mixed prior to injection or is mixed subsequent to injection