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Here is a breakdown of the latest blockbuster deal between Abbott and Novo Nordisk India, and what it means for the booming GLP-1 market

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Patients maintained these gains even after dose escalation, suggesting the mechanism remains effective across the therapeutic range rather than developing tolerance

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doi: 10.1038/s41586-021-03539-7 39 McCulloughK

(2) Metformin increases the concentration of GLP-1 in the gastrointestinal tract by inhibiting the activation of dipeptidyl peptidase-4 (DPP4), which in turn reduces the degradation of GLP-1 by DPP4 in the gastrointestinal tract (McCreight et al., 2016)