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Both are growth hormonereleasing peptides, but tesamorelin is FDA-approved for reducing visceral fat in HIV-related lipodystrophy, while ipamorelin is more commonly used in wellness and performance settings.

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This specificity allows Ipamorelin to trigger GH release without significantly impacting other hormones such as cortisol, prolactin, or ACTH, making it a favorable option for those seeking GH supplementation with minimal side effects

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