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Because they have to be consumed orally and pass through the digestive process

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doi: 10.1093/ajcn/33.6.1179 213 YoungVRNewbernePM

(PubMed) Wald DS, Law M, Morris JK

Several studies reported DMEs could respond to the hepatic steatosis by protecting hepatocytes from free radicals 6,7 , additionally, GSTs are always considered as the scavenger of reactive oxygen species