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doi:10.1200/JCO-24-01349 Ahn MJ, Tanaka K, Paz-Ares L, et al

Clin Oncol

Recipe created on: 5/9/2026

SLC25A40 knockdown destabilized ETC Complexes I, II, and III, elevated cytosolic and mitochondrial ROS, and upregulated Gclc and Gclm genes essential for GSH synthesis

The absence of clinical guidelines leaves surgeons navigating an evidence gap with potential medicolegal implications, particularly when patients undergo elective procedures where the acceptable tolerance for unmeasured risk is low