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This problem is rooted in the models structure

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PDEs activity For kinetic analysis of PDEs activity, the PDEs, 3,5-nucleotides, and cAMP (Abcam plc, Cambridge, UK), were used at concentrations ranging from 0.3 M to 40 M of cAMP and the reaction interval was 30 min according to the instrumental procedure

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HSP90 inhibitors Heat shock protein 90 (HSP90) is a chaperone involved in cellular homeostasis in different physio-pathological conditions, such as cancer

[5] In eukaryotes, this is a homodimeric enzyme